This study shows that CM at the GEJ is a common histologic finding in a chiefly Korean population, and 4.4% showed direct continuity of oxyntic mucosa and squamous epithelium even in single biopsy specimens. composed of stratified squamous epithelium overlying a connective tissue proper, or lamina propria. Goblet cells typically grow in the intestines, but with chronic reflux of stomach contents into the esophagus, the normal lining of 2 Reflux-associated changes of the esophageal squamous epithelium were assessed according to the Esohisto consensus guidelines. Squamous mucosa without significant histopathologic changes. Introduction. Nasal polyps (NPs) are nonneoplastic, chronic inflammatory outgrowths of the respiratory mucosa that usually arise bilaterally from the middle meatus and ethmoid sinus. - Scant unremarkable squamous epithelium. Squamous Metaplasia of Uterine Cervix is a benign condition and there is no risk for a malignant transformation. The second are squamous cells, which cover the exterior surface of the cervix where it is inside the vagina. Mild Chronic Inflammatory Infiltrate Symptom Checker: Possible causes include Gingival Fibromatosis 5. Associated lesions, such as inflammation, should not be diagnosed separately unless warranted by severity. In ulcerative colitis, chronic active inflammation tends to involve rectal mucosa in the proximal anal canal. 18 These cells have microvilli along their luminal membrane and contain numerous mitochondria. Keratinizing squamous metaplasia, also termed leukoplakia, is more common in men and is usually associated with chronic irritation, such as indwelling catheters, calculi, and schistosomiasis. - NEGATIVE FOR DYSPLASIA AND NEGATIVE FOR MALIGNANCY. This should be brought to the knowledge of a gynecologist and be monitored by him/her. This word Read More. It is called squamous mucosa when the top layer is made up of squamous cells. Is Tauriel Teaches Typing A Horror Game, Easy Jewish Cookie Recipes, Burma Superstar Temescal, Arlec 7 Day Timer Instructions, Samsung Galaxy Z Fold 3 Unlocked, The tongue is covered with squamous epithelium or mucosa, therefore, they said it was benign or normal squamous mucosa with hyperkeratosis. 1 Because of the ease and frequency of use of upper endoscopy for diagnosing gastrointestinal (GI) illnesses, biopsy specimens procured from -- Ectocervical mucosa with cervicitis and focal squamous atypia, favor reactive. "Carditis" is another controversial term. I have a patch on my tongue and i had a biopsy done the result was benign squamous mucosa with hyperkeratosis. what does that mean? Hyperkeratosis: The tongue is covered with squamous epithelium or mucosa, therefore, they said it was benign or normal squamous mucosa with hyperkeratosis. Lymphoma: Patchy chronic inflammation is seen. In ulcerative colitis, chronic active inflammation tends to involve rectal mucosa in the proximal anal canal. Reflux, or "acid reflux", means regurgitation of the acid stomach contents up into the esophagus. Chronic inflammatory cells do not cause the nuclear abnormalities associated with active inflammation. Check the full list of possible causes and conditions now! A number of things, including chronic reflux (regurgitation) of stomach contents up into 1 AB/PAS stain positive for intestinal acid mucin all mean. Unlike the ulcers in Crohn's disease, the ulcers seen in ulcerative colitis are surrounded by inflamed mucosa. Unlike normal colonic mucosa, however, inflamed colonic mucosa demonstrates abnormalities in various molecular pathways before histologic evidence of dysplasia or cancer. Changes in skin color. Like nasopharyngeal carcinoma, but not often associated with EBV. Anal adenocarcinoma The inflammation and excess fluid in the area causes the mucosal layer to be very fragile, and it bleeds easily. oral mucosa. squamous esophageal mucosa with mild reactive changes. Investigation of the prognostic determinants is significant for the expectations of treatment proposal and cure of the patient. Similarly, you may ask, what is squamous mucosa of the esophagus? Squamous cells are flat cells that look similar to fish scales when viewed under the microscope. also. Most common in -- Small fragments of endocervical mucosa with mild inflammation. Most of the esophagus is lined by squamous mucosa. Histologic features of abscesses and fistulas include acute and chronic inflammation, granulation tissue, and fibrosis; a foreign body giant cell reaction to fecal material may be present. Most of the esophagus is lined by squamous mucosa. Squamous hyperplasia should be diagnosed and graded based on the size, thickness, and number of hyperplastic areas. The patient had undergone excision of a poorly differentiated squamous cell carcinoma from the mucosa of the left cheek, a few months before. Results: Chronic inflammation at the gastroesophageal junctional mucosa (carditis) was detected in 790 (75%) of 1053 patients. It has been recognized as a significant risk factor for the development of carcinoma of the urinary mucosa, the majority of which are squamous cell carcinoma. -- No cervical transformation zone or squamous component is present in this biopsy. Doctors typically provide answers within 24 hours. 3 thanks. Lymphoepithelial Carcinoma: Sheets of pleomorphic cells with a prominent intratumor chronic inflammatory infiltrate. 118 Similar to its cervical counterpart, ACIN has been identified in anal mucosa adjacent to invasive carcinomas of the anal canal, as well as as an incidental finding in resection specimens from this region. In cervicovaginitis, the cervical and vaginal mucosa respond to infection with an inflammatory reaction that is characterized by damage to surface cells. She had noticed a chronic irritation of the septal mucosa and bleeding from the left nostril some weeks before she consulted an ENT-surgeon. The inflammation and excess fluid in the area causes the mucosal layer to be very fragile, and it bleeds easily. They also contain both mucoid and nonmucoid secretory granules. Histological examination of a mass of few fused lymph nodes, isolated from left laterocervical lymphadenectomy, showed metastatic squamous cell carcinoma with concomitant granulomatous inflammation. The esophagus reacts to the injury and tries to repair itself. Associated lesions, such as inflammation, should not be diagnosed separately unless warranted by severity. Primary squamous cell carcinoma (SCC) of the renal pelvis is a rare occurrence, accounting for only 0.57.0% of upper urinary tract tumours [1,2,3,4,5].Due to its rarity together with the association with nephrolithiasis and chronic inflammation, it may present a diagnostic challenge to the urologist. In moderate ulcerative colitis, ulcers develop. Discomfort and inflammation are common, and thick, irregular patches of gray or white skin develop. However, the transformation zone of metaplastic change (within the cervix) is very vulnerable to human papilloma virus infection, which is a sexually-transmitted disease. Alimentary tract mucositis involves both oral and gastrointestinal mucosal injury, ranging from the oral to the anal mucosa.. Carditis at the Z-line was focal in 49% of the specimens and was always present adjacent to the squamous epithelium. Lymphoma: (2) Mucositis occurs when cancer treatments break down the rapidly The word inactive in the diagnosis means that no specialized immune cells called neutrophils were seen damaging the epithelium. Dr. Justin Diedrich answered. If histologic findings are encountered more distally in the anal canal, they are limited to nonspecific chronic inflammation of the submucosal tissues with associated mild reactive changes of the squamous or transitional epithelium. [] Reactive hyperplastic lesions represent the most frequently encountered oral mucosal lesions in humans. There is hyperplasia of the squamous epithelium of the hard palate. HPV infects and transforms the squamous cells of the cervix. Biopsy specimens were obtained from gastric antrum and corpus, immediately distal to normal-appearing squamocolumnar junction and distal esophagus. Squamous mucosa with nonspecific chronic inflammation Cervix, biopsy: Squamocolumnar junction mucosa with dense inflammation, ulceration and epithelial viral cytopathic changes consistent with herpes simplex infection Differential diagnosis. Here is chronic cervicitis in the squamous epithelium at the right, with non-inflamed non-keratinizing squamous mucosa at the left. Figure 2 Oral mucosa - Associated lesions, such as inflammation, should not be diagnosed separately unless warranted by severity. A number of things, including chronic reflux (regurgitation) of stomach contents up into 1 Histopathologically, numerous papillary projections are usually covered by hyperplastic stratified squamous epithelium with or without chronic inflammation. The condition can be diagnosed by a Pap smear and tissue culture studies. Chronic inflammatory cells do not cause the nuclear abnormalities associated with active inflammation. Sign out Mildly inflamed VULVA, BIOPSY: - SQUAMOUS MUCOSA WITH MILD CHRONIC INFLAMMATION AND REACTIVE CHANGES. The remaining tissue at the ulcer site (called the ulcer bed) is composed of granulation The mucosal lining of the "gastric cardia" is highly variable, and only infrequently consists of cardiac mucosa in endoscopically normal patients . - NEGATIVE FOR DYSPLASIA AND NEGATIVE FOR MALIGNANCY. Chronic GVHD (cGVHD) targets several regions not affected by acute GVHD (aGVHD), including the oropharynx, the upper portion of the esophagus, and the anogenital region. There is hyperplasia of the squamous epithelium of the hard palate. Your treating physician will work with you to treat your reflux, which can help prevent additional abnormalities from developing in your esophagus. Negative for dysplasia or malignancy. Therefore, the presence of these two cell types on the pap smear simply means that the sample is an adequate one for ruling out the presence of cancer or a precancerous lesion. Squamous Metaplasia of Uterine Cervix is a benign condition and there is no risk for a malignant transformation. As the disease progresses, the ulcers can become larger and more continuous. Inflammation. Nonetheless, it is easy to identify the location of the ulcer, where the mucosa has been lost. Squamous mucosa is the term for the inner lining of the esophagus. Inflammation. Localized hair loss. A. Cervix, between 10:00-11:00 oclock, mild squamous dysplasia B. Cervix, 4:00 o'clock biopsy: Acute and Chronic inflammation with squamous atypia, favor reactive process February 7, 2022 notre dame football 2020. Biopsies with esophagitis average greater than six lymphocytes per hpf (25). Dry skin. certain illnesses, such as diabetes or kidney failure. Most classifications now separate chronic otitis media into two distinct types:. The remaining tissue at the ulcer site (called the ulcer bed) is composed of granulation Dr. Justin Diedrich answered. Inflammatory disorders of the esophagus are extremely common. The Endosalpingiosi Read More. Here is chronic cervicitis in the squamous epithelium at the right, with non-inflamed non-keratinizing squamous mucosa at the left. What does mildly hyperplastic esophageal squamous mucosa suggesting mild reflux induce injury,cardiac type gastric mucosa with moderate nonspecific chronic inflammation, and focus of goblet cell metoplasia, consistent with Barrett's esophagus. More discussions about squamous metaplasia. The most common cause of infection is the bacteria Helicobacter pylori (also known as just H. pylori). Most of the esophagus is lined by squamous mucosa. RESULTS Mean carditis scores and percentages of patients with a positive carditis score were higher in Z-line biopsy specimens containing both squamous and columnar mucosa than in those with just columnar mucosa or in specimens taken 12 cm below the Z-line. The oral mucosa is constantly subjected to external and internal stimuli and therefore manifests a spectrum of diseases that range from developmental, reactive and inflammatory to neoplastic. When the stomach gets infected with this bacteria, it can cause problems like gastritis (irritation of the stomach) and These regions are surfaced by nonkeratinized squamous mucosa and have similar histology: chronic lymphocytic inflammation with variable apoptosis of the surface. (Negative for gastric mucosa or intestinalized (Barrett's) mucosa.) Download scientific diagram | Proximal esophagus biopsy shows squamous mucosa with mild chronic inactive inflammation (hematoxylin and eosin stain; original magnification 100). Squamous occurs due to retraction of the tympanic membrane and is associated with the formation of cholesteatoma; Mucosal occurs due to In moderate ulcerative colitis, ulcers develop. Histologically, the squamous mucosa of the oesophagus accurately defines this area, but distinguishing normal gastric cardia and metaplastic changes of the distal oesophagus may be difficult. The mucosal lining of the "gastric cardia" is highly variable, and only infrequently consists of cardiac mucosa in endoscopically normal patients . An outward tumor growth (exophytic) is seen in most cases; sometimes, an inward tumor growth (endophytic) that can constrict the vagina is known to occur. Note the orderly maturation in the squamous mucosa but disorderly maturation, sometimes with almost an abrupt transition from immature to mature epithelium as shown here. Most cervical cancers and pre-cancers are caused by infections with human papillomavirus (HPV). Oral Mucosa Hyperplasia, Squamous Squamous in a female F344/N rat from chronic study. 897 views Answered >2 years ago. However, they are very conspicuous in patients with GERD (24). The Endosalpingiosi Read More. Most classifications now separate chronic otitis media into two distinct types:. Normal and Inflammatory: -- No diagnostic abnormality. 5.3 Role of Infections in OSCC. Conclusions: Two dissimilar types of chronic inflammation of the gastric cardia mucosa seem to occur, one existing in conjunction with chronic H. pylori gastritis and the other with normal stomach and erosive GERD. Chronic inflammation of the vagina: treatment and relationship to autoimmunity. It is called squamous mucosa when the top layer is made up of squamous cells. 94-96, 95, 96 IBD may be associated with manifestations of chronic inflammation and I had my first abnormal pap December 18, 2009 which showed HPV. 0/250. What does mildly hyperplastic esophageal squamous mucosa suggesting mild reflux induce injury,cardiac type gastric mucosa with moderate nonspecific chronic inflammation, and focus of goblet cell metoplasia, consistent with Barrett's esophagus. -- Small fragments of endocervical mucosa with mild inflammation. Thank. Chronic otitis media (COM) is an inflammatory disorder of the middle ear.It is characterised by persistent or recurrent ear discharge. The inner lining of the esophagus is known as the mucosa. The gastric epithelium has been artifactually lost over both of these sections. (Negative for gastric mucosa or intestinalized (Barrett's) mucosa.) The benign squamous mucosa is consistent with the upper vaginal wall. Mucositis is an acute inflammatory and ulcerative complication of the mucosal membrane that commonly occurs during cancer therapy. To have a constant meaning, carditis must be defined as an inflammation of histologically defined cardiac mucosa, irrespective of location. Squamous cells are flat cells that look similar to fish scales when viewed under the microscope. Apart from common inflammatory conditions like gingivitis, periodontitis, or mucositis, linkup between oral microbiota and In moderate ulcerative colitis, ulcers develop. As this pattern continues, the skin becomes excoriated, or worn down. White oral mucosal lesions often result from an increase in the thickness of the surface keratin layer that may develop from a variety of etiologic pathways, including but not limited to traumatic, inflammatory and neoplastic. What does it mean if it also says that the cardiac-type mucosa has inflammation? The benign squamous mucosa is consistent with the upper vaginal wall. The inner lining of the esophagus is known as the mucosa. A. The diverse and symbiotic microbiome plays a vital role in maintenance of oral health. Apart from common inflammatory conditions like gingivitis, periodontitis, or mucositis, linkup between oral microbiota and Nonetheless, it is easy to identify the location of the ulcer, where the mucosa has been lost. A. Negative for dysplasia or malignancy. In the gastric cardia, inflammation is found as part of GERD in the absence of Helicobacter pylori or other causes of gastritis (carditis). Inflammatory disorders of the esophagus are extremely common. aka Sarcomatoid carcinoma or Carcinosarcoma In cervicovaginitis, the cervical and vaginal mucosa respond to infection with an inflammatory reaction that is characterized by damage to surface cells. The squamous mucosa is Histologic changes indicative of gastroesophageal reflux disease (GERD) are found on both sides of the squamocolumnar junction (Z-line). Adenosquamous Carcinoma: Arises from squamous epithelium but shows both squamous and glandular differentiation. An oral examination revealed a 4 cm area of irregular mucosa with underlying nodularity and 2 cm ulceration with fibrinous debris just lateral to the left retromolar trigone and several areas of early ulceration. Squamous mucosa without significant histopathologic changes. It can be triggered by allergies, irritating chemicals and other factors. 6. Squamous metaplasia is a benign non-cancerous change of surfacing lining cells to a squamous morphology . The local immune response Unlike the ulcers in Crohn's disease, the ulcers seen in ulcerative colitis are surrounded by inflamed mucosa. Therefore, the presence of these two cell types on the pap smear simply means that the sample is an adequate one for ruling out the presence of cancer or a precancerous lesion. The diverse and symbiotic microbiome plays a vital role in maintenance of oral health. - NEGATIVE for dysplasia. 94-96, 95, 96 IBD may be associated with manifestations of chronic inflammation and Gastroesophageal reflux disease (GERD) is among the most common chronic conditions, affecting as much as 40% of people in the Western world. CI of the vaginal mucosa stems from local immune activation and is generally associated with evidence of other immune abnormalities, including autoimmune diseases and disorders in which immune activation play a part, including endometriosis. 5.3 Role of Infections in OSCC. The sections show squamous mucosa with a mild chronic inflammatory infiltrate that consists predominantly of lymphocytes. Lichen planus* is a chronic inflammatory disease involving skin and oral mucosa. (GE junction, biopsy:) Gastroesophageal junctional mucosa with chronic inflammation and reactive changes(, non-specific. Comment: This is in keeping with an "inlet patch", also known as "heterotopic gastric mucosal patch of the proximal esophagus". Esophagus at 22 cm, Biopsy: - Gastric type mucosa with mild chronic inactive inflammation, see comment. On occasion, biopsy specimens from the cardia show an increase in the amount of acute and chronic inflammatory cells, a condition termed carditis. What are reactive changes? (2) Mucositis occurs when cancer treatments break down the rapidly The term cervicovaginitis refers to inflammation of the squamous epithelium of the vagina and cervix. The sections show squamous mucosa with a mild chronic inflammatory infiltrate that consists predominantly of lymphocytes. Prolonged acute inflammation or repeated bouts of acute inflammation may lead to the appearance of more mononuclear cells, and chronic inflammation. 2 Endoscopically, reflux esophagitis was evaluated by Los Angeles (LA) classification, hiatal hernias were classified by Hill grade, and gastroesophageal flap valves were assessed. It can also infect and transform the cells of other tissues in the body. Thank. The tongue is covered with squamous epithelium or mucosa, therefore, they said it was benign or normal squamous mucosa with hyperkeratosis. Most of the esophagus is lined by squamous mucosa. Its also known as mild dysplasia. The gastric epithelium has been artifactually lost over both of these sections. Adenosquamous Carcinoma: Arises from squamous epithelium but shows both squamous and glandular differentiation. squamous esophageal mucosa with mild reactive changes. The columnar-lined mucosa at the gastroesophageal junction may contain an inflammatory infiltrate, commonly referred to as carditis (or cardia gastritis). Squamous cells are flat cells that look similar to fish scales when viewed under the microscope. The existence and origin of cardiac mucosa (CM) at the GEJ is debated, but most data were from a Western population. stress. AB/PAS stain positive for intestinal acid mucin all mean. However, the transformation zone of metaplastic change (within the cervix) is very vulnerable to human papilloma virus infection, which is a sexually-transmitted disease. To have a constant meaning, carditis must be defined as an inflammation of histologically defined cardiac mucosa, irrespective of location. Traditional teaching holds that the normal stomach has three types of mucosae. Negative for intestinalized (Barrett's) mucosa.) Ask U.S. doctors your own question and get educational, text answers it's anonymous and free! Gastroesophageal junction, biopsy: -Unremarkable squamous and gastric mucosa. Note the orderly maturation in the squamous mucosa but disorderly maturation, sometimes with almost an abrupt transition from immature to mature epithelium as shown here. i'm hpv high risk pos. What are reactive changes? Lichen planus is a T cellmediated inflammatory autoimmune condition affecting the skin and mucosal surfaces. Outlook. Infiltrated by mixed inflammatory cells, including lymphocytes, plasma cells, eosinophils, neutrophils and mast cells Surface epithelium can show ulceration or squamous metaplasia May have bizarre stromal cells (large and pleomorphic) Submucosal glands are decreased or absent Concurrent fungal infection may be seen Mucositis is defined as inflammation of the oral and gastrointestinal mucosa secondary to cancer therapies. Most cervical cancers and pre-cancers are caused by infections with human papillomavirus (HPV). aka Sarcomatoid carcinoma or Carcinosarcoma Pathologists describe this change as chronic inflammation. from February 7, 2022 notre dame football 2020. The nuclear membranes are regular. The diverse and symbiotic microbiome plays a vital role in maintenance of oral health. It means that part of the mucose on the cervix area has changes from a certain kind of mucose cells to another, and that there is a bit of an inflammation around it. Oral squamous cell carcinoma (OSCC) is the eleventh most prevalent solid tumor worldwide, responsible for approximately 4% of all malignancies [ 10 ]. Most of the esophagus is lined by squamous mucosa. Download scientific diagram | Proximal esophagus biopsy shows squamous mucosa with mild chronic inactive inflammation (hematoxylin and eosin stain; original magnification 100). -No dysplasia or malignancy. Eczema is also called dermatitis. Chronic otitis media (COM) is an inflammatory disorder of the middle ear.It is characterised by persistent or recurrent ear discharge. What are reactive changes? Some people develop goblet cells on the lining of the esophagus instead of squamous cells, which is called intestinal metaplasia or Barretts esophagus. Figure 2 Oral mucosa - Hyperplasia, Squamous in a female F344/N rat from chronic study (higher magnification of Figure 1). Micro. A. Most squamous cell carcinomas are seen in the upper vagina (top 1/3 portion); the lower vaginal tract may be affected by non-HPV related SCCs. Ask U.S. doctors your own question and get educational, text answers it's anonymous and free! EoE is a chronic inflammatory disorder characterized by eosinophilic infiltration of the esophageal mucosa associated with a history of atopy or allergy. 897 views Answered >2 years ago. As the disease progresses, the ulcers can become larger and more continuous. Lichen planus is a chronic systemic disease of established immune-mediated pathogenesis. The squamous mucosa shows reactive features including basal layer hyperplasia and elongation of the submucosa papillae. Normally, the mucosa of the cardia is composed of tightly packed mucus secreting glands with a lamina propria devoid of any significant inflammatory component. On cervical biopsy what does ectocervical squamous mucosa w/ inflammation and reactive changes mean? The lining is referred to as squamous mucosa because of the presence of squamous cells. Squamous cells carcinoma is the most important malignant tumor with primary site in the oral cavity and, given the great exposure of mucosa and lips to the etiologic factors of this neoplasm, its incidence is high. This should be brought to the knowledge of a gynecologist and be monitored by him/her. Eczema causes itching, redness and tiny blisters. inflammation is found in the absence of Helicobacterpylori or other known causes of gastritis (carditis); the squamous mucosa is most likely to show inflammatory changes such as neutrophils or eosinophils close to the Z line, while traditional reactive changes in the squamous mucosa remain valid only in biopsies taken at least 3 cm above the Zliie. 43 In these studies, active and chronic inflammation was only found in patients with reflux disease (neutrophils, lymphocytes, and plasma cells). Squamous cells are flat cells that look similar to fish scales when viewed under the microscope. Squamous Cell Carcinoma Factors that cause chronic irritation and esophageal mucosa inflammation may increase the risk for esophageal squamous cell carcinoma. These factors include moderate-to-heavy alcohol drinking, smoking, achalasia, diverticuli, and consumption of extremely hot beverages, coarse grains or seeds, lye, and caustic spices. The location of the lesion (e.g., gingival, palatal) should be noted in the pathology narrative. There is hyperplasia of the squamous epithelium of the hard palate. More discussions about squamous metaplasia. lymphocytosis in the peripapillary region along with spongiosis and basal cell hyperplasia of esophageal squamous mucosa. 2 1 The polyps are lined by pseudostratified respiratory epithelium. Squamous mucosa with nonspecific chronic inflammation Cervix, biopsy: Squamocolumnar junction mucosa with dense inflammation, ulceration and epithelial viral cytopathic changes consistent with herpes simplex infection Differential diagnosis. The basement membrane is variably thickened and in some instances has underlying areas of stromal hyalinization. Thus it appeared to the authors of this study that cardiac mucosa is a gastric mucosal derivative and not a metaplasia in the lower squamous esophagus. chronic marijuana user and smoked twice daily. squamous esophageal mucosa with mild reactive changes The Blog. study. -- Diffuse prominent acute and chronic cervicitis. Histologically, the columnar epithelium of squamocolumnar junction, presence and severity of acute and chronic inflammation, atrophy, intestinal metaplasia, and presence of carditis were evaluated. 5.3 Role of Infections in OSCC. Similarly, you may ask, what is squamous mucosa of the esophagus? (being completely replaced by squamous epithelium) the criterion of mucosal surface involvement by atypical epithelium cannot be used to make the diagnosis of dysplasia. 0/250. The features are those of reflux esophagitis. Mild trauma, and constant irritation to the oral mucosa histologically manifests as acanthosis and hyperparakeratosis. They are part of the inflammatory response Targeted esophageal and gastric mucosal biopsies showed erosive esophagitis with many colonies of Sarcina species and chronic gastritis with H. pylori infection, respectively (Figure 2). -- No cervical transformation zone or squamous component is present in this biopsy. My last normal pap was in March of 2008. On examination, the patient had left-sided facial swelling with overlying erythema. [] These lesions represent a reaction to some kind Russell body gastritis/duodenitis is an unusual form of chronic gastrointestinal mucosal inflammation, characterized by abundant plasma cells containing eosinophilic cytoplasmic globules.